Dementia-friendly OUtdoor BuilT environmentS. Evidence among Outdoor air pollution, Artificial Light At Night (ALAN), Greenness and Dementia.

Andrea Rebecchi (Principal Investigator)

The interest in the role of environment on human health is increasing in recent years, led to the implementation of several methodologies for the assessment of exposure, including the use of big data (satellite-based dataset). DOUBTS objective is to assess the relation with relevant and emerging environmental factors (Outdoor air pollution, Artificial Light At Night (ALAN) and Greenness) related to climate change factors, and risk of dementia. The specific objectives are: – validating available environmental data to model cases and control exposure; – testing the relevance of environmental pollutants and the availability of green spaces and infrastructures in modifying the risk of young-onset dementia in two Italian Provinces (Modena & Pavia); – evaluating the role of Outdoor air pollution, ALAN and Greenness on disease progression. Natural cubic splines and conditional logistic regression models will be used, stratifying for potential confounders such as education and socioeconomic status, and effect-modifiers such as age and sex, and disease subtypes.

Contribution to SDGs: 3, 10, 11